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Adv. Gerontol.-2007.-Vol. 20, № 4.-P. 40-47

IA. Vinogradova, A.V. Bukalev, M. A. Zabezhinski¹, A. V. Semenchenko¹, V. N. Anisimov¹

effect of light regimens and melatonin on the homeostasis, life span and development of spontaneous tumors in female rats

Petrozavodsk State University, 33 Lenina pr., Petrozavodsk, 185910; e-mail: irinav@petrsu.ru; ¹ Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, 68 Leningradskaja st., St. Petersburg 197758, e-mail: aging@mail.ru

Effect of different light regimens (standard - 12 hours of light/12 hours of darkness, natural light­ning of the North-West of Russia and constant illumination) and melatonin on the homeostasis, life span parameters and spontaneous tumor development of female rats was studied. Animals at condi­tions of constant or natural light regimens revealed accelerated aging of organism, decrease of mean (by 13,5 % and 25,5 % accordingly) and the maximal life span (by 9 and 7 months, accordingly) and faster spontaneous tumor development as compared with the animals kept at the standard light regi­men. Melatonin given in nocturnal drinking water (10 mg /l) prevented the adverse effect of the natural light regimen on the homeostasis, life span and tumor development. Melatonin also decreased sponta­neous tumor development, first of all, mammary and uterine neoplasm, in the rats kept at the constant illumination.

Key words: light regimen, melatonin, homeostasis, life span, spontaneous tumors, fe­male rats.

47

УСПЕХи геронтологии • 2007 • Т. 20, № 4

© Коллектив авторов, 2007 г УДК 613.648:612.67

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