Морфофункциональное состояние гонадотропоцитов аденогипофиза на ранних этапах возрастной инволюции

6, № 6.-P. 540-546.

4. Eeken J.C.J., Sobels F.H., Hyland V., Schalet A.P. Distri­bution of MR-induced sex-linked recessive lethal mutation in Drosophila melanogaster// Mutat. Res.-1985.-Vol. 150.-

P. 261-275.

5. Guarente L., Kenyon C. Genetic pathways that regulate ageing in model organisms // Nature.-2000.-Vol. 409.-

P. 255-262.

Adv. Gerontol.-2007.-Vol. 20, № 4.-P. 36-39

AA. Moskalev, E.N. Plyusnina

DROSOPHILA MELANOGASTER recessive lethal mutation in x-cromosome locus 6D1-7A2 in heterozygote leads to life span increasing

Institute of biology of Komi Science Center of Ural division of RAS, 28 Kommunisticheskaya ul., 167982 Syktyvkar, Russia; e-mail: amoskalev@ib.komisc.ru

The results of demographic analysis of survival of different Drosophila lines have shown that re­cessive lethal mutation located in X-chromosome locus 6D1-7A2, as compared with wild type strain, in heterozygote leads to aging speed deceleration (decreasing of mortality trajectory slope), median (20%) and maximal (15-20%) life span increasing. Further investigations (complementation analysis with duplicated loci) will enable to discover, whether it is unknown life span gene.

Key words: Drosophila, aging, X-chromosome, life span genes.

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УСПЕХи геронтологии • 2007 • Т. 20, № 4

© Коллектив авторов, 2007 г Успехи геронтол.-2007-Т. 20, № 4.-С. 40-47

УДК 613.165+612.018]:616-006:599.323.4

И.А. Виноградова, А.В. Букалев, М.А. Забежинский1, А.В

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