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AA. Moskalev, E.N. Plyusnina
DROSOPHILA MELANOGASTER recessive lethal mutation in x-cromosome locus 6D1-7A2 in heterozygote leads to life span increasing
Institute of biology of Komi Science Center of Ural division of RAS, 28 Kommunisticheskaya ul., 167982 Syktyvkar, Russia; e-mail: amoskalev@ib.komisc.ru
The results of demographic analysis of survival of different Drosophila lines have shown that recessive lethal mutation located in X-chromosome locus 6D1-7A2, as compared with wild type strain, in heterozygote leads to aging speed deceleration (decreasing of mortality trajectory slope), median (20%) and maximal (15-20%) life span increasing. Further investigations (complementation analysis with duplicated loci) will enable to discover, whether it is unknown life span gene.
Key words: Drosophila, aging, X-chromosome, life span genes.
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УСПЕХи геронтологии • 2007 • Т. 20, № 4
© Коллектив авторов, 2007 г Успехи геронтол.-2007-Т. 20, № 4.-С. 40-47
УДК 613.165+612.018]:616-006:599.323.4
И.А. Виноградова, А.В. Букалев, М.А. Забежинский1, А.В
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