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Adv. Gerontol.-2007.-Vol. 20, № 4.-P. 61-63

Yu.P. Miljutina1,2, L.S. Kozina1, A.V. Arutjunyan2, N.I. Chalisova3, V.V. Lesnjak1, P.Yu.

Morozova3

the effect of Pineal Peptide preparations on prohferative Activity on MEDIOBASAL

hypothalamus organotypic tissue culture

1 St.Petersburg Institute of Bioregulation and Gerontology, 3 Dynamo pr., St.Petersburg 197110, Russia; e­mail: ibgu@medport.ru; 2 D.O. Ott Institute of Obstetrics and Gynecology of RAMS, 3 Mendeleevskaya Liniya, St.Petersburg 199034, Russia; e-mail: arutjunyan@aa3703.spb.edu; 3I.P. Pavlov Institute of Physiology of RAS, 6 Makarov nab., St.Petersburg 199034, Russia; e-mail: ni_chalisova@mail.ru

In investigations carried out with organotypic culture of mediobasal preoptic area (MPA) of hypo­thalamus it was established that pineal peptide preparations epitalon (2 ng/ml) and epithalamin (100 ng/ml) stimulate the development of proliferative activity of explants in 3 month and 24 months female rats. It has been shown that epithalamin is more effective in young rats in comparison with old animals, but epitalon as well as epithalamin have almost the same less pronounced inducing effect on growth zone in MPA explants from young and old animals. This effect is tissue specific and could be dependent on inhibition of apoptosis.

Key words: hypothalamus, epithalamin, epitalon, organotypic culture, explant.

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